BIOCHEMICAL INVESTIGATIONS ON THE EFFECT OF AQUEOUS LEAF EXTRACT OF ICACINA TRICHANTA OLIV. ON UREA, CREATININE AND KIDNEY OXIDATIVE STATUS IN CCL4-INDUCED RENAL DYSFUNCTION IN RATS.

Different parts of Icacina trichanta has been used for ethnomedicinal purposes; this study was undertaken to investigate the effects plant on CCl4- induced renal damage. Phytochemical analyses were carried out powdered sample using standard procedures. Absolute organ weight, Urea, creatinine, total protein, superoxide dismutase, catalase and malondialdehyde levels determined. Consequently, thirty-six male albino rats divided into six groups each. They fed rats‘ chow water ad libitum. Groups I (normal control) III not induced. While group administered 400 mg extract/kg body wt. rats, extract. II (negative control), IV, V VI with 1.0 ml CCl4/kg 200, 300 b.wt animals respectively 14 days. Results phytochemical revealed presence alkaloids, saponins, tannins polyphenolics. CCl4 induction significantly raised urea, protein lipid peroxidation status rats. These ameliorated administration graded doses